Bark and leaves are used for the tincture and infusion (medicinal tea). Spondias mombin is a broad spectrum antiseptic and antibacterial and may be comparable to those of Ampicillin* and Gentamycin**.
Constituents
The leaves and bark contain tannins, saponins, flavonoids, sterols, quinones, antioxidants and other
phyto-chemicals such as caryophyllene.
In addition, the leaves contain salicylic acid derivatives and chlorogenic acid.
Pharmacology
Sedative, anti-epileptic and antipsychotic effects of Spondias mombin leaves in methanol and ethanol solvents results suggest
that the leaves extracts of Spondias mombin possess sedative and antidopaminergic effects. The extracts of the leaf of Spondias mombin exhibited
wide spectrum antibacterial effects comparable to those of Ampicillin and Gentamycin. There is justification for the use of this little
studied medicinal plant as anti-infective agents in traditional medicine.
Applications
A decoction and extract of the astringent bark serves as an emetic, a remedy for diarrhea, dysentery, hemorrhoids and a treatment
for gonorrhea and leucorrhea.
In Suriname, the bark is considered anti-inflammatory and analgesic. It is and for inflammations and painful conditions like
arthritis, rheumatism, menstrual pain, cramps and irregularity. The leaves are used for digestive and as an antimicrobial for infections.
Extracts from the leaves induce labor and used as an abortive.
Used as a nervine against anxiety and stress; Spondias mombin leaves, extracted with aqueous,
methanol and ethanol decreased the amphetamine/apomorphine-induced stereotyped behavior, which suggest that these extracts possess antidopaminergic activity.
The effect of these extracts on hexobarbitone-induced sleeping time was blocked by flumazenil a GABAA antagonist, indicating that the extracts contain GABAA agonists.
These results suggest that the leaves extracts of the leaves possess sedative and anti-dopaminergic effects.
Do not use when pregnant (unless under the supervision of a medical practitioner).
If allergic to aspirin or salicylic acid, do not use of the leaves tincture or infusion.
Drug interactions, due to the sedative and anti-anxiety effects of the leaves,
a tincture and infusion may enhance the effects of other sedative and anti-anxiety medications.
*Ampicillin is a penicillin-like antibiotic used to treat certain infections caused by bacteria such as pneumonia; bronchitis; and ear, lung, skin, and urinary tract infections.
Brand names: Principen®
**Gentamycin (or gentamicin) is a aminoglycoside antibiotic, and can treat many different types of bacterial infections, particularly Gram-negative infections.
Brand Name(s): Garamycin® ; Gentak® ; Spectro-Genta® ; Alcomicin® ; Genoptic®
Reference
Sedative, antiepileptic and antipsychotic effects of Spondias mombin L. (Anacardiaceae) in mice and rats.
Abiodun O. Ayokaa, Rufus O. Akomolafea, Ezekiel O. Iwalewab,
Moses A. Akanmub and Otas E. Ukponmwana.
a Department of Physiological Sciences, Obafemi Awolowo University, P.O. Box 1282, Ile-Ife, Osun State, Nigeria.
b Departments of Pharmacology, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
Received 20 August 2004; revised 25 July 2005; accepted 27 July 2005. Available online 26 September 2005.
The above presentation is for informational and educational purposes only.
It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage.
For many of the conditions discussed, treatment with prescription or over - the - counter medication is also available.
Consult your doctor, practitioner, and / or pharmacist for any health
problem and before using dietary supplements or before making any changes in prescribed medications.
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