A tall tree, indigenous to the Amazon rainforest, growing up to more than 60 feet in
height with smooth grayish bark. The parts that are used medicinally, are the inner-bark and leaves.
The bark is odorless, difficult to powder, and very bitter.
The powdered or chopped up bark is used for the following conditions: Infections (candida yeast, parasitic, respiratory)
and prostatitis.
Quassinoids, responsible for the anti-amebic and anti-malarial properties, have also shown to possess active
anticancer properties.
As traditional medicine in Suriname, it is used in the latter stage of dysentery, when the stomach is not affected.
It restores the lost tone of the intestines, promotes the secretions, and disposes the patient to sleep.
From its use, it has been called "Dysentery bark".
It is also employed in the treatment of malaria and used as a tonic.
Pharmacology
The quassinoids, responsible for the anti-amebic and antimalarial properties, have
also shown in clinical research to possess active cancer-killing properties.in vitro. Researchers found that also another Simarouba quassinoid, (holacanthone)
possessed antileukemic and anti-tumorous actions in 1983. Researchers in the UK cited the antitumorous activity
of two of the quassinoids, (ailanthinone and glaucarubinone) against human epidermoid carcinoma of the pharynx.
A later study demonstrated the antitumorous activity of glaucarubinone against solid tumors (human and mouse
cell lines), multi-drug-resistant mammary tumors in mice, and antileukemic activity against leukemia in mice.
Tincture: 1 - 3 ml daily Infusion: 1 - 2 cups / daily.
Children (10 years): one half of the adult doses.
Children (14 years): three quarter of the adult doses.
Adults: 30 drops (1 ml) : 2 - 3 times a day in water or juice.
Side effects and / or interactions
Nausea and dizziness.
Do not take while pregnant or breast feeding.
References
Morre, D.J., et al. "Effect of the quassinoids glaucarubolone and simalikalactone D on growth of
cells permanently infected with feline and human immunodeficiency viruses and on viral infections." Life Sci. 1998; 62(3): 213-9.
Rahman, S., et al. "Anti-tuberculosis activity of quassinoids." Chem. Pharm. Bull. 1997; 45(9): 1527-9.
Kaif-A-Kamb, M., et al. "Search for new antiviral agents of plant origin." Pharm. Acta Helv. 1992; 67(5-6): 130-147.
Polonsky, J. "The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba
amara." Experientia. 1978; 34(9): 1122-23. Ghosh, P.C., et al. "Antitumor plants. IV. Constituents of Simarouba versicolor."
Lloydia. 1977; 40(4): 364-69. Ogura, M. et al. "Potential anticancer agents VI. Constituents of Ailanthus excelsa (Simaroubaceae)."
Lloydia. 1977; 40(6): 579-84.
The above presentation is for informational and educational purposes only.
It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage.
For many of the conditions discussed, treatment with prescription or over - the - counter medication is also
available.
Consult your doctor, practitioner, and / or pharmacist for any health problem and before using
dietary supplements or before making any changes in prescribed medications.
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