Zingiber aromaticum also called Puyang is a medicinal plant; a beautiful ginger, originally from Indonesia. The bioactive sesquiterpenoid zerumbone (2,6,9 humulatriene-8-one) has anticancer properties. This plant may be effective as an anticancer agent and it also exhibited HIV-inhibitory. Other applications of the rhizome (the medicinal part of this plant) are: rhizome used as a tonic, for whooping cough, as a stomachic and analgesic.
Pharmacology
Tincture:The anticancer properties of zerumbone (2,6,9 humulatriene-8-one), a sesquiterpenoid from Zingiber aromaticum were compared with those of curcumin from Curcuma longa. Extract of C. longa was as effective at one-seventh the concentration of curcumin as the positive control. Zerumbone is effective as an anticancer agent, possibly by its apoptosis-inducing and antiproliferative influences. The medicinal properties of Zerumbone can be summarized as follows:
suppresses free radical generation; suppresses cancer cell proliferation accompanied by apoptosis; anti-HIV activity, anti-inflammatory.
An Indonesian researcher has found an herbal formula to ward off bird flu virus on chicken, saying that there is a possibility of using the formula to other poultry and human. He said, the formula basically comprised four traditional medicinal plants: Java chili powder (piper retrofactum), white turmeric extract (Curcuma xanthorriza), temu ireng extract (Curcuma aeruginosa) and powder of fragrant wild ginger (Zingiber aromaticum). He mixed these four materials with honey bees, cane sugar and some water.
Zerumbone is a natural product found in the gingers Zingiber aromaticum and Zingiber zerumbet.
Constituents
Zerumbone (2,6,9 humulatriene-8-one); 2,3-epoxy-6,9-humuladien-5-ol-8-one ,2,3-epoxy-6,9-humuladien-5-ol-8-one ; these are all sesquiterpenoids. kaempferol-3-O-(2,3-di-O-acetyl- -L-rhamnopyranoside); kaempferol-3-O-(2,3,4-tri-O-acetyl- L-rhamnopyranoside) these are flavonol glycosides.
Dosage
Tincture: 0.5 – 3 ml daily
References
Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. Kirana C, McIntosh GH, Record IR, Jones GP.
CSIRO Health Sciences and Nutrition, PO Box 10041, Kintore Avenue, Adelaide DC, South Australia 5000. chandra.kirana@hsn.csiro.edu
Sesquiterpenes and Flavonol Glycosides from Zingiber aromaticum and Their CYP3A4 and CYP2D6 Inhibitory Activities
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-0194, Japan, Mitsubishi Chemical Safety Institute Ltd., 14-Sunayama, Ibaraki 314-0255,
Japan, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Tokyo 192-0392, Japan, and 21st Century COE Program
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