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PUYANG TINCTURE
 (tinctura ZINGIBER AROMATICUM)

 from AMAZON HERBS®



Zingiber aromaticum Overview

Zingiber aromaticum also called Puyang is a medicinal plant; a beautiful ginger, originally from Indonesia.
In Asia, it is used as treatment for various ailments including malignancies.
The bioactive sesquiterpenoid zerumbone (2,6,9 humulatriene-8-one) has anticancer properties; it makes up 38% of the rhizome (plant part used).
This plant may be effective as an anticancer agent and it also exhibited HIV-inhibitory.
The bioactive compound Zerumbone (cytotoxic) displayed strong apoptosis (programmed cell death) against many cancer cell types but not or far less against healthy cells.
It has high potential in preventing and controlling carcinogenesis.
It is effective against ischaemic liver disease (Hepatocellular carcinoma). It shows also al lot of potential as a treatment for leukemia and tumors.
Other applications of the rhizome (the medicinal part of this plant) are: rhizome used as a tonic, for whooping cough, as a stomachic and analgesic.

Pharmacology

Tincture: the anticancer properties of zerumbone (2,6,9 humulatriene-8-one), a sesquiterpenoid from Zingiber aromaticum were compared with those of curcumin from Curcuma longa. Extract of C. longa was as effective at one-seventh the concentration of curcumin as the positive control. Zerumbone is effective as an anticancer agent, possibly by its apoptosis-inducing and antiproliferative influences.
The medicinal properties of Zerumbone can be summarized as follows:
suppresses free radical generation; suppresses cancer cell proliferation accompanied by apoptosis; anti-HIV activity, anti-inflammatory.

In an important study, Zerumbone significantly showed an antiproliferative activity upon HepG2 cells with an IC50 of 3.45 ± 0.026 µg/ml. Zerumbone was also found to inhibit the proliferation of non-malignant Chang Liver and MDBK cell lines.
Hepatocellular carcinoma (HCC) is one of the most common malignancies, characterized by high incidence in hepatitis B virus-associated cirrhotic liver disease.
Bioactive components from herbal plants have high potential in preventing and controlling carcinogenesis.
Zerumbone displayed a selective cytotoxic characteristic towards cancer cell lines and normal cell lines. This bioactive compound induced HepG2 cell death via apoptosis or necrosis.
In this study, Zerumbone was compared to Cisplatin, a drug with antineoplastic activity. Cisplatin is used widely in the treatment of ovarian, bladder and testicular cancer. Zerumbone performed better in tests.
Zerumbone is a natural product found in the gingers Zingiber aromaticum and zerumbet.

Constituents

Zerumbone (2,6,9 humulatriene-8-one); 2,3-epoxy-6,9-humuladien-5-ol-8-one ,2,3-epoxy-6, 9-humuladien-5-ol-8-one ; these are all sesquiterpenoids. kaempferol-3-O-(2,3-di-O-acetyl- -L-rhamnopyranoside); kaempferol-3-O-(2,3,4-tri-O-acetyl- L-rhamnopyranoside) these are flavonol glycosides.

Dosage

Tincture: ½ - 3 droppers (0.5 - 3 ml) daily

For more information on Zingiber aromaticum and zerumbet go to:
"MAROWINA FACTS® DATABASE"..

References

 Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone.
KIRANA C, MCINTOSH GH, RECORD IR, JONES GP.
CSIRO Health Sciences and Nutrition, PO Box 10041, Kintore Avenue, Adelaide DC, South Australia 5000.

Sesquiterpenes and Flavonol Glycosides from Zingiber aromaticum and Their CYP3A4 and CYP2D6 Inhibitory Activities
TEPY USIA, HIROSHI IWATA, AKIRA HIRATSUKA, TADASHI WATABE, SHIGETOSHI KADOTA, and YASUHIRO TEZUKA
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-0194, Japan, Mitsubishi Chemical Safety Institute Ltd., 14-Sunayama, Ibaraki 314-0255, Japan, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Tokyo 192-0392, Japan, and 21st Century COE Program

Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio.
SHARIFAH SAKINAH SA, TRI HANDAYANI S, AZIMAHTOL HAWARIAH LP
School of Bioscience and Biotechnology, Faculty of Science and Technology, National University of Malaysia (UKM), 43600 Bangi, Selangor, Malaysia



 The above presentation is for informational and educational purposes only.
It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage.
For many of the conditions discussed, treatment with prescription or over - the - counter medication is also available.
Consult your doctor, practitioner, and / or pharmacist for any health problem and before using dietary supplements or before making any changes in prescribed medications.



Buy 6 bottles save 10%; buy 12 bottles and save 15%!
Item Description Unit Price Quantity
Zingiber aromaticum tincture 1 fl. oz (29.6 cc) U$ 10.35
Zingiber aromaticum tincture 6 x 1 fl. oz U$ 55.89
Zingiber aromaticum tincture 12 x 1 fl. oz U$ 105.57
Zingiber aromaticum tincture 2 fl. oz (59.1 cc) U$ 18.65
Zingiber aromaticum tincture 6 x 2 fl. oz U$ 100.71
Zingiber aromaticum tincture 12 x 2 fl. oz U$ 190.23


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