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| TONKA TINCTURE (tinctura DIPTERYX ODORATA) from AMAZON HERBS® |
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OverviewTonka tincture has been used extensively in the flavoring of cured tobacco leaves but there are also other applications: It is traditionally used for snakebites, cuts, contusions, coughs and rheumatism. In traditional medicine in Surinam, Cumaru (Tonka) is considered to have antispasmodic, emmenagogue, cardio-tonic and anti-asthmatic actions. The tonka bean contains coumarin which condensed derivatives are used as an anti-coagulant (blood thinner). The beans can contain 1% - 3% coumarin. However, some strains have tested as high as 10%. It acts as a strong antagonist to vitamin K and prevents blood coagulation. The derivatives of coumarin are commercially marketed as a prescription drug: Coumadin© (Warfarin). Potential cancer chemo-preventive constituents from the seeds of Dipteryx odorata (Tonka bean) have been identified by research. Pharmacology Heartwood extracts from Dipteryx odorata exhibit antioxidant activities comparable with that of α-tocopherol, a well-known antioxidant; this is one of several forms of vitamin E. A new cassane diterpene, dipteryxic acid (1), and a new isoflavonolignan, 5-methoxyxanthocercin A (2), as well as four known active compounds, isoliquiritigenin (3), 6,4'-dihydroxy-3'-methoxyaurone (4), sulfuretin (5), and (+/-)-balanophonin (6), and five known inactive compounds, butin, eriodictyol, 7-hydroxychromone, 7,3'-dihydroxy-8,4'-dimethoxyisoflavone, and (-)-lariciresinol, were isolated from an ethyl acetate-soluble extract of the seeds of Dipteryx odorata, using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa 1c1c7 mouse hepatoma cells to monitor chromatographic fractionation. The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation. Single-crystal X-ray diffraction analysis was used to confirm the relative stereochemistry of compound 1. Selected compounds (3-5) were evaluated in a mouse mammary organ culture assay, with isoliquiritigenin (3) found to exhibit 76% inhibition at a dose of 10 microg/mL. For more information on Tonka, go to the "MAROWINA FACTS® DATABASE". Dosage Tincture: check with your herbal- or homeopathic health provider. Warning The beans (seeds) are considered poisonous. Internal use is not recommended. May be hepatotoxic. Do not use in together with blood thinning drugs. Reference Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean). Dae Sik Jang, Eun Jung Park, Michael E Hawthorne, Jose Schunke Vigo, James G Graham, Fernando Cabieses, Bernard D Santarsiero, Andrew D Mesecar, Harry H S Fong, Rajendra G Mehta, John M Pezzuto, A Douglas Kinghorn Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 60612, USA Heartwood extractives from the Amazonian trees Dipteryx odorata, Hymenaea courbaril, and Astronium lecointei and their antioxidant activities. Takanori Imai, Sousuke Inoue, Naomi Ohdaira, Yasuyuki Matsushita, Rie Suzuki, Mariko Sakurai, José Manoel Henriques de Jesus, Salete Kiyoka Ozaki, Zenesio Finger and Kazuhiko Fukushima The above presentation is for informational and educational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage. For many of the conditions discussed, treatment with prescription or over - the - counter medication is also available. Consult your doctor, practitioner, and / or pharmacist for any health problem and before using dietary supplements or before making any changes in prescribed medications. |
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